Holmes and Wagenseil, JBME, 2016, Guest Editorial

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This special issue of JBME highlights frontiers and challenges in
cardiovascular biomechanics. Nine young investigators have contributed
to this special issue [1–9]. Experimental work ranges from
individual smooth muscle cells to engineered cardiac tissue to
whole arteries. Modeling work ranges from predicting cardiomyocyte
responses to optogenetic stimuli to patient-specific ventricular
mechanics. In this commentary, we both summarize the work showcased
in this issue and discuss some of the current frontiers and
challenges in the field. We highlight significant advances in growth
and remodeling (G&R) and patient-specific computational models,
as well as technical and economic considerations for the future utility
of such models. We discuss experimental models that move
beyond cell culture and the relevance of tissue biomechanics, especially
when tissue-specific mechanics can be readily altered with
genetic engineering. Finally, we touch on changes in the funding
landscape for cardiovascular biomechanics.